Cross-stage immunity for malaria vaccine development
نویسندگان
چکیده
منابع مشابه
Pregnancy-associated malaria: parasite binding, natural immunity and vaccine development.
Humans living in areas of high malaria transmission gradually acquire, during the early years of life, protective clinical immunity to Plasmodium falciparum, limiting serious complications of malaria to young children. However, pregnant women become more susceptible to severe P. falciparum infections during their first pregnancy. Pregnancy associated malaria is coupled with massive accumulation...
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M ALARIA IS ONE of the major parasitic diseases affecting humans today, contributing greatly to the high mortality rates in the developing world. The original epidemiologic concept of “malaria eradication” for large endemic areas, introduced by the World Health Organization (WHO) in the 1960s, has now been replaced by the concept of “control,” given the increase in the morbidity and mortality r...
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Cross-Species Immunity in Malaria Vaccine Development: Two, Three, or Even Four for the Price of One? Bruno Douradinha,† Maria M. Mota, Adrian J. F. Luty,* and Robert W. Sauerwein Department of Medical Microbiology, University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Unidade Malaria, Instituto de Medicina Molecular, Universidade de Lisboa, 1649-028 Lisboa, Portugal; and...
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Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the li...
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The development of a vaccine against malaria is a major research priority given the burden of disease, death and economic loss inflicted upon the tropical world by this parasite. Despite decades of effort, however, a vaccine remains elusive. The best candidate is a subunit vaccine termed RTS,S but this provides only partial protection against clinical disease. This review examines what is known...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2015
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2015.09.098